Fig. 1
From: The sensitivity of mTORC1 signaling activation renders tissue regenerative capacity
The sensitivity of mTORC1 signaling activation stimulates regeneration in lower vertebrates
Upon injury, growth factors and nutrients promote mTORC1 translocation to the lysosome, and mTORC1 activation is rapidly induced in the axolotl amputation model. When activated, mTORC1 controls different processes of protein synthesis, such as cap-dependent translation and ribosome biosynthesis, through phosphorylating 4E-BP1 and S6K1. Zhulyn et al. showed that the rapid protein synthesis mediated by mTORC1 activation drives wound healing and blastema formation, which lead to the consequent complete restoration of the damaged tissues. Thus, manipulation of mTOR signaling activity might facilitate organism regeneration in mammals.