Table 1 Time-courses of the wound response and repair in C. elegans epidermis
From: From wound response to repair – lessons from C. elegans
Phase | Key Biological Processes | Time |
|---|---|---|
Response phase (Transcriptional- independent) | Ca2+ influx mitochondrial Ca2+ uptake Mitochondrial fragmentation mtROS production Actin polymerization | Milliseconds –seconds Seconds Seconds Seconds - minutes Minutes |
Repair phase (Transcriptional activation) | Cytochrome P450 upregulations SYX-2 and EFF-1 induction AMPs induction SYX-2 recruitment EFF-1 recruitment | 30 min to hours 30 min to hours Hours 30 min to hours Hours |
Remodeling phase | scar formation | > 6 h |