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Table 1 Time-courses of the wound response and repair in C. elegans epidermis

From: From wound response to repair – lessons from C. elegans

Phase Key Biological Processes Time
Response phase (Transcriptional- independent) Ca2+ influx
mitochondrial Ca2+ uptake
Mitochondrial fragmentation
mtROS production
Actin polymerization
Milliseconds –seconds
Seconds
Seconds
Seconds - minutes
Minutes
Repair phase (Transcriptional activation) Cytochrome P450 upregulations
SYX-2 and EFF-1 induction
AMPs induction
SYX-2 recruitment
EFF-1 recruitment
30 min to hours
30 min to hours
Hours
30 min to hours
Hours
Remodeling phase scar formation >  6 h
  1. The events listed above are highly interconnected with spatial-temporal overlaps