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Correction to: CRISPR/Cas: a potential gene-editing tool in the nervous system

The Original Article was published on 06 August 2020

Correction to: Cell Regeneration (2020) 9:12

https://doi.org/10.1186/s13619-020–00,044-6

Following publication of the original article (Gao et al. 2020 [1]), it is reported that the “Background” section and the heading “Main Text” need to be added to the article.

The Background section has been provided below.

Background

The CRISPR/Cas system is gaining more and more popularity in gene editing and therapy since first discovered in 1987. Up to now, on one hand, different types of the CRISPR/Cas system were discovered to improve its size, editing efficiency and PAM limitations; on the other hand, by fusing different factors to the mutant Cas protein which inactivates its nuclease activity but retains its ability to bind a specific DNA target site by a guide RNA, different types of engineered CRISPR/Cas9 tools were developed to perform modification of a specific gene, like DNA methylation or demethylation, histone acetylation or deacetylation and so on. Here, we briefly introduce these tools and their applications in the nervous system.

The original article (Gao et al. 2020 [1]) has been updated.

Reference

  1. 1.

    Gao Y, Gao K, Yang H. CRISPR/Cas: a potential gene-editing tool in the nervous system. Cell Regen. 2020;9:12. https://doi.org/10.1186/s131619-020-00044-6.

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Correspondence to Hui Yang.

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Gao, Y., Gao, K. & Yang, H. Correction to: CRISPR/Cas: a potential gene-editing tool in the nervous system. Cell Regen 10, 35 (2021). https://doi.org/10.1186/s13619-021-00095-3

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  • DOI: https://doi.org/10.1186/s13619-021-00095-3