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  1. The conversion of somatic cells into pluripotent stem cells via overexpression of reprogramming factors involves epigenetic remodeling. DNA methylation at a significant proportion of CpG sites in induced pluri...

    Authors: Aline C Planello, Junfeng Ji, Vivek Sharma, Rajat Singhania, Faridah Mbabaali, Fabian Müller, Javier A Alfaro, Christoph Bock, Daniel D De Carvalho and Nizar N Batada

    Citation: Cell Regeneration 2014 3:4

    Content type: Research

    Published on:

  2. Zinc-finger nucleases and transcription activator-like effector nucleases are novel gene-editing platforms contributing to redefine the boundaries of modern biological research. They are composed of a non-spec...

    Authors: Yu Wang, Nana Fan, Jun Song, Juan Zhong, Xiaogang Guo, Weihua Tian, Quanjun Zhang, Fenggong Cui, Li Li, Philip N Newsome, Jon Frampton, Miguel A Esteban and Liangxue Lai

    Citation: Cell Regeneration 2014 3:3

    Content type: Methodology

    Published on:

  3. Oct4 is a transcription factor that plays a major role for the preservation of the pluripotent state in embryonic stem cells as well as for efficient reprogramming of somatic cells to induced pluripotent stem ...

    Authors: Eva Harreither, Hanna A Rydberg, Helene L Åmand, Vaibhav Jadhav, Lukas Fliedl, Christina Benda, Miguel A Esteban, Duanqing Pei, Nicole Borth, Regina Grillari-Voglauer, Oliver Hommerding, Frank Edenhofer, Bengt Nordén and Johannes Grillari

    Citation: Cell Regeneration 2014 3:2

    Content type: Research

    Published on:

  4. Genomic datasets and the tools to analyze them have proliferated at an astonishing rate. However, such tools are often poorly integrated with each other: each program typically produces its own custom output i...

    Authors: Andrew Paul Hutchins, Ralf Jauch, Mateusz Dyla and Diego Miranda-Saavedra

    Citation: Cell Regeneration 2014 3:1

    Content type: Methodology

    Published on:

  5. Human pluripotent stem cells (hPSCs) are able to self-renew indefinitely and to differentiate into all adult cell types. hPSCs therefore show potential for application to drug screening, disease modelling and ...

    Authors: Jack W Lambshead, Laurence Meagher, Carmel O'Brien and Andrew L Laslett

    Citation: Cell Regeneration 2013 2:7

    Content type: Review

    Published on:

  6. Tooth is vital not only for a good smile, but also good health. Yet, we lose tooth regularly due to accidents or diseases. An ideal solution to this problem is to regenerate tooth with patients’ own cells. Her...

    Authors: Jinglei Cai, Yanmei Zhang, Pengfei Liu, Shubin Chen, Xuan Wu, Yuhua Sun, Ang Li, Ke Huang, Rongping Luo, Lihui Wang, Ying Liu, Ting Zhou, Shicheng Wei, Guangjin Pan and Duanqing Pei

    Citation: Cell Regeneration 2013 2:6

    Content type: Research

    Published on:

  7. Zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) have been successfully used to knock out endogenous genes in stem cell research. However, the deficiencies of current g...

    Authors: Renli Ru, Yongchao Yao, Songlin Yu, Benpeng Yin, Wanwan Xu, Siting Zhao, Li Qin and Xiaoping Chen

    Citation: Cell Regeneration 2013 2:5

    Content type: Methodology

    Published on:

  8. In Type 1 diabetes, the insulin-producing β-cells within the pancreatic islets of Langerhans are destroyed. We showed previously that immunotherapy with Bacillus Calmette-Guerin (BCG) or complete Freund’s adju...

    Authors: Thomas Hill, Olga Krougly, Enayat Nikoopour, Stacey Bellemore, Edwin Lee-Chan, Lynette A Fouser, David J Hill and Bhagirath Singh

    Citation: Cell Regeneration 2013 2:2

    Content type: Research

    Published on:

  9. We are now well entering the exciting era of stem cells. Potential stem cell therapy holds great promise for the treatment of many diseases such as stroke, traumatic brain injury, Alzheimer’s disease, Parkinso...

    Authors: Yunying Liu, Ru Yang, Zuping He and Wei-Qiang Gao

    Citation: Cell Regeneration 2013 2:1

    Content type: Review

    Published on:

  10. Studying embryonic hematopoiesis is complicated by diversity of its locations in the constantly changing anatomy and by the mobility of blood cell precursors. Embryonic hematopoietic progenitors are identified...

    Authors: Igor M Samokhvalov

    Citation: Cell Regeneration 2012 1:9

    Content type: Review

    Published on:

  11. Pluripotency is depicted by a self-renewing state that can competently differentiate to form the three germ layers. Different stages of early murine development can be captured on a petri dish, delineating a s...

    Authors: Jolene Ooi and Pentao Liu

    Citation: Cell Regeneration 2012 1:7

    Content type: Review

    Published on:

  12. With their capability to undergo unlimited self-renewal and to differentiate into all cell types in the body, induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells of individual patients with...

    Authors: Zhen-Ning Zhang and Yang Xu

    Citation: Cell Regeneration 2012 1:5

    Content type: Review

    Published on:

  13. Notch is one of the most important signaling pathways involved in cell fate determination. Activation of the Notch pathway requires the binding of a membrane-bound ligand to the Notch receptor in the adjacent ...

    Authors: Wenguang Yin, Dapeng Liu, Nian Liu, Liangliang Xu, Song Li, Shuo Lin, Xiaodong Shu and Duanqing Pei

    Citation: Cell Regeneration 2012 1:4

    Content type: Research

    Published on:

  14. Cell-based therapies show promise in repairing cardiac tissue and improving contractile performance following a myocardial infarction. Despite this, ischemia-induced death of transplanted cells remains a major...

    Authors: Curtis C Hughey, Maria P Alfaro, Darrell D Belke, Jeffery N Rottman, Pampee P Young, David H Wasserman and Jane Shearer

    Citation: Cell Regeneration 2012 1:3

    Content type: Short report

    Published on:

  15. To develop and characterize a novel cell culture method for the generation of undifferentiated and differentiated human mesenchymal stem cell 3D structures, we utilized the RWV system with a gelatin-based scaf...

    Authors: Wolfgang H Cerwinka, Starlette M Sharp, Barbara D Boyan, Haiyen E Zhau, Leland W K Chung and Clayton Yates

    Citation: Cell Regeneration 2012 1:2

    Content type: Research

    Published on:

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