Articles

Generation of functional organs from stem cells

We are now well entering the exciting era of stem cells. Potential stem cell therapy holds great promise for the treatment of many diseases such as stroke, traumatic brain injury, Alzheimer’s disease, Parkinso...

Authors: Yunying Liu, Ru Yang, Zuping He and Wei-Qiang Gao

Return to the hematopoietic stem cell origin

Studying embryonic hematopoiesis is complicated by diversity of its locations in the constantly changing anatomy and by the mobility of blood cell precursors. Embryonic hematopoietic progenitors are identified...

Authors: Igor M Samokhvalov

Using mouse models to study function of transcriptional factors in T cell development

Laboratory mice have widely been used as tools for basic biological research and models for studying human diseases. With the advances of genetic engineering and conditional knockout (CKO) mice, we now underst...

Authors: Peng Li, Yiren Xiao, Zhixin Liu and Pentao Liu

Pluripotency and its layers of complexity

Pluripotency is depicted by a self-renewing state that can competently differentiate to form the three germ layers. Different stages of early murine development can be captured on a petri dish, delineating a s...

Authors: Jolene Ooi and Pentao Liu

A feeder-free, human plasma-derived hydrogel for maintenance of a human embryonic stem cell phenotype in vitro

Human embryonic stem cells (hESCs) represent a tremendous resource for cell therapies and the study of human development; however to maintain their undifferentiated state in vitro they routinely require the use o...

Authors: Fiona C Lewis, Nicholas Bryan and John A Hunt

Progress and bottleneck in induced pluripotency

With their capability to undergo unlimited self-renewal and to differentiate into all cell types in the body, induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells of individual patients with...

Authors: Zhen-Ning Zhang and Yang Xu

SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1

Notch is one of the most important signaling pathways involved in cell fate determination. Activation of the Notch pathway requires the binding of a membrane-bound ligand to the Notch receptor in the adjacent ...

Authors: Wenguang Yin, Dapeng Liu, Nian Liu, Liangliang Xu, Song Li, Shuo Lin, Xiaodong Shu and Duanqing Pei

Increased oxygen consumption and OXPHOS potential in superhealer mesenchymal stem cells

Cell-based therapies show promise in repairing cardiac tissue and improving contractile performance following a myocardial infarction. Despite this, ischemia-induced death of transplanted cells remains a major...

Authors: Curtis C Hughey, Maria P Alfaro, Darrell D Belke, Jeffery N Rottman, Pampee P Young, David H Wasserman and Jane Shearer

Differentiation of human mesenchymal stem cell spheroids under microgravity conditions

To develop and characterize a novel cell culture method for the generation of undifferentiated and differentiated human mesenchymal stem cell 3D structures, we utilized the RWV system with a gelatin-based scaf...

Authors: Wolfgang H Cerwinka, Starlette M Sharp, Barbara D Boyan, Haiyen E Zhau, Leland W K Chung and Clayton Yates

Cell regeneration- bridging discoveries in applied and basic research

Authors: Duanqing Pei