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  1. High-throughput phenotypic screening is a cornerstone of drug development and the main technical approach for stem cell research. However, simultaneous detection of activated core factors responsible for cell ...

    Authors: Jun Li, Jun Chi, Yang Yang, Zhongya Song, Yong Yang, Xin Zhou, Yang Liu and Yang Zhao
    Citation: Cell Regeneration 2023 12:22
  2. The regeneration capacity after an injury is critical to the survival of living organisms. In animals, regeneration ability can be classified into five primary types: cellular, tissue, organ, structure, and wh...

    Authors: Yun Zhao, Chong Gao, Xue Pan and Kai Lei
    Citation: Cell Regeneration 2023 12:14
  3. Adipose tissues are essential for actively regulating systemic energy balance, glucose homeostasis, immune responses, reproduction, and longevity. Adipocytes maintain dynamic metabolic needs and possess hetero...

    Authors: Jiayin Ye, Cheng Gao, Yong Liang, Zongliu Hou, Yufang Shi and Ying Wang
    Citation: Cell Regeneration 2023 12:13

    The Correction to this article has been published in Cell Regeneration 2023 12:20

  4. Hematopoietic stem cells (HSCs) are critical for the treatment of a variety of hematological diseases. However, the low number of HSCs lead to the clinical application difficult. To gain more functional human ...

    Authors: Guixian Liang and Feng Liu
    Citation: Cell Regeneration 2023 12:18
  5. Steatosis, as the early stage of nonalcoholic fatty acid disease (NAFLD), would progress into nonalcoholic steatohepatitis (NASH) and liver failure without intervention. Despite the development of animal model...

    Authors: Jinsong Wei, Wen Zhang and Bing Zhao
    Citation: Cell Regeneration 2023 12:17
  6. EAF1 and EAF2, the eleven-nineteen lysine-rich leukemia (ELL)-associated factors which can assemble to the super elongation complex (AFF1/4, AF9/ENL, ELL, and P-TEFb), are reported to participate in RNA polyme...

    Authors: WenYe Liu, ShuHui Lin, LingYa Li, ZhiPeng Tai and Jing-Xia Liu
    Citation: Cell Regeneration 2023 12:10
  7. Liver is an organ with notable capacity of regeneration. Reprogramming of hepatocytes towards an immature state is one of the important mechanisms for hepatocyte replenishment. Inflammatory response mediated b...

    Authors: Ruopu Li, Deqiang Li and Yu Nie
    Citation: Cell Regeneration 2023 12:16
  8. Spinal motor neurons deficiency results in a series of devastating disorders such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and spinal cord injury (SCI). These disorders are current...

    Authors: He Jax Xu, Yao Yao, Fenyong Yao, Jiehui Chen, Meishi Li, Xianfa Yang, Sheng Li, Fangru Lu, Ping Hu, Shuijin He, Guangdun Peng and Naihe Jing
    Citation: Cell Regeneration 2023 12:15
  9. Preclinical models that can accurately predict the toxicity and efficacy of candidate drugs to human liver tissue are in urgent need. Human liver organoid (HLO) derived from human pluripotent stem cells offers...

    Authors: Xiaoshan Wu, Dacheng Jiang, Yi Yang, Shuang Li and Qiurong Ding
    Citation: Cell Regeneration 2023 12:6
  10. Regeneration, as a fascinating scientific field, refers to the ability of animals replacing lost tissue or body parts. Many metazoan organisms have been reported with the regeneration phenomena, but showing ev...

    Authors: Jiru Zhong, Andi Jing, Shaojuan Zheng, Sheng Li, Xiaoshuai Zhang and Chonghua Ren
    Citation: Cell Regeneration 2023 12:9
  11. Spatial transcriptomics, which combine gene expression data with spatial information, has quickly expanded in recent years. With application of this method in liver research, our knowledge about liver develop...

    Authors: Jia He, Chengxiang Deng, Leonard Krall and Zhao Shan
    Citation: Cell Regeneration 2023 12:11
  12. The overlapping roles of Hippo and Hedgehog signaling in biological functions and diseases prompt us to investigate their potential interactions. Activation of Hippo signaling enhances the transcriptional outp...

    Authors: Chao Tang, Jirong Wang, Minli Yao, Xing Ji, Wei Shi, Chengyun Xu, Ling-Hui Zeng and Ximei Wu
    Citation: Cell Regeneration 2023 12:3
  13. Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by multiple genetic and environmental factors. Numerous genes are implicated in the etiology of IBD, but the diagnosis of IBD is chal...

    Authors: Shicheng Yu, Mengxian Zhang, Zhaofeng Ye, Yalong Wang, Xu Wang and Ye-Guang Chen
    Citation: Cell Regeneration 2023 12:8
  14. De novo organ regeneration is the process in which adventitious roots or shoots regenerate from detached or wounded organs. De novo organ regeneration can occur either in natural conditions, e.g. adventitious roo...

    Authors: Qihui Wan, Ning Zhai, Dixiang Xie, Wu Liu and Lin Xu
    Citation: Cell Regeneration 2023 12:1
  15. Myelopoiesis is the process in which the mature myeloid cells, including monocytes/macrophages and granulocytes, are developed. Irregular myelopoiesis may cause and deteriorate a variety of hematopoietic malig...

    Authors: Yang-Xi Hu and Qing Jing
    Citation: Cell Regeneration 2023 12:2
  16. Deer antlers constitute a unique mammalian model for the study of both organ formation in postnatal life and annual full regeneration. Previous studies revealed that these events are achieved through the proli...

    Authors: Hengxing Ba, Xin Wang, Datao Wang, Jing Ren, Zhen Wang, Hai-Xi Sun, Pengfei Hu, Guokun Zhang, Shengnan Wang, Chao Ma, Yusu Wang, Enpeng Wang, Liang Chen, Tianbin Liu, Ying Gu and Chunyi Li
    Citation: Cell Regeneration 2022 11:43
  17. Cell fate transition is a fascinating process involving complex dynamics of three-dimensional (3D) chromatin organization and phase separation, which play an essential role in cell fate decision by regulating ...

    Authors: Xiaoru Ling, Xinyi Liu, Shaoshuai Jiang, Lili Fan and Junjun Ding
    Citation: Cell Regeneration 2022 11:42
  18. Skeletal muscle plays a critical role in human health. Muscle stem cells (MuSCs) serve as the major cell type contributing to muscle regeneration by directly differentiating to mature muscle cells. MuSCs usual...

    Authors: Xin Fu, Cheng-le Zhuang and Ping Hu
    Citation: Cell Regeneration 2022 11:40
  19. Intestinal organoids, derived from intestinal stem cell self-organization, recapitulate the tissue structures and behaviors of the intestinal epithelium, which hold great potential for the study of development...

    Authors: Fanlu Meng, Congcong Shen, Li Yang, Chao Ni, Jianyong Huang, Kaijun Lin, Zanxia Cao, Shicai Xu, Wanling Cui, Xiaoxin Wang, Bailing Zhou, Chunyang Xiong, Jihua Wang and Bing Zhao
    Citation: Cell Regeneration 2022 11:39
  20. Malignant glioma is a highly heterogeneous and invasive primary brain tumor characterized by high recurrence rates, resistance to combined therapy, and dismal prognosis. Glioma stem cells (GSCs) are likely res...

    Authors: Xin-Xin Han, Chunhui Cai, Li-Ming Yu, Min Wang, Wenhan Yang, Dai-Yu Hu, Jie Ren, Lu-Ying Zhu, Jia-Jia Deng, Qing-Qing Chen, Hua He and Zhengliang Gao
    Citation: Cell Regeneration 2022 11:36
  21. Central nervous system (CNS) neurons typically fail to regenerate their axons after injury leading to neurological impairment. Axonal regeneration is a highly energy-demanding cellular program that requires lo...

    Authors: Ning Huang and Zu-Hang Sheng
    Citation: Cell Regeneration 2022 11:33
  22. Cilia are microtubule-based organelles projected from most eukaryotic cell surfaces performing cell motility and signaling. Several previously recognized non-ciliary proteins play crucial roles in cilium forma...

    Authors: Kaiming Xu and Guangshuo Ou
    Citation: Cell Regeneration 2022 11:29

    The Correction to this article has been published in Cell Regeneration 2022 11:41

  23. The CCCTC-binding factor (CTCF) protein and its modified forms regulate gene expression and genome organization. However, information on CTCF acetylation and its biological function is still lacking. Here, we ...

    Authors: Shixin Gong, Gongcheng Hu, Rong Guo, Jie Zhang, Yiqi Yang, Binrui Ji, Gang Li and Hongjie Yao
    Citation: Cell Regeneration 2022 11:34
  24. Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo. Chimeric mouse brains have been created by engrafting human fetal tissue- or pluripotent stem cell-derived progeni...

    Authors: Peng Jiang and Mahabub Maraj Alam
    Citation: Cell Regeneration 2022 11:32
  25. Reprogramming somatic cells to pluripotent stem cells has revolutionized the biomedical field by providing enormous hopes and opportunities for the regeneration of tissues and organs for transplantation. Using...

    Authors: Deepti Abbey
    Citation: Cell Regeneration 2022 11:27
  26. Mouse embryonic stem cells (mESCs) cycle in and out of a transient 2-cell (2C)-like totipotent state, driven by a complex genetic circuit involves both the coding and repetitive sections of the genome. While a...

    Authors: Lu Li, Pishun Li, Jiale Chen, Li Li, Yunfan Shen, Yangzixuan Zhu, Jiayi Liu, Lu Lv, Song Mao, Fang Chen, Guang Hu and Kai Yuan
    Citation: Cell Regeneration 2022 11:25
  27. Pancreatic β cells differentiated from stem cells provide promise for cell replacement therapy of diabetes. Human pluripotent stem cells could be differentiated into definitive endoderm, followed by pancreatic...

    Authors: Wenwen Jin and Wei Jiang
    Citation: Cell Regeneration 2022 11:24

    The Correction to this article has been published in Cell Regeneration 2022 11:30

  28. Malignant Glioma is characterized by strong self-renewal potential and immature differentiation potential. The main reason is that malignant glioma holds key cluster cells, glioma stem cells (GSCs). GSCs contr...

    Authors: Xin-Xin Han, Shengkai Jin, Li-Ming Yu, Min Wang, Xin-Yu Hu, Dai-Yu Hu, Jie Ren, Meng-Han Zhang, Wei Huang, Jia-Jia Deng, Qing-Qing Chen, Zhengliang Gao, Hua He and Chunhui Cai
    Citation: Cell Regeneration 2022 11:23
  29. Mesenchymal stem cells (MSCs)-based therapy has displayed some promises in ischemia heart diseases although its efficacy may be affected by changes in surrounding environments. This study evaluated the role of...

    Authors: Xing Qin, Juanjuan Fei, Yu Duan, Asli F. Ceylan, Fuyang Zhang and Jun Ren
    Citation: Cell Regeneration 2022 11:21
  30. Adult mammalian cardiomyocytes are unable to proliferate to regenerate lost tissue after heart injury. Du et al., reporting in Cell Stem Cell, employ a FUCCI- and MADM-based system to screen for small molecules c...

    Authors: Nevan Powers and Guo N. Huang
    Citation: Cell Regeneration 2022 11:20
  31. Animal models are widely used for biomedical studies and drug evaluation. The small intestine plays key roles in nutrient absorption, hormone secretion, microbiota defense and drug absorption and metabolism. A...

    Authors: Haonan Li, Xiaodan Wang, Yalong Wang, Mengxian Zhang, Fan Hong, Hong Wang, Along Cui, Jianguo Zhao, Weizhi Ji and Ye-Guang Chen
    Citation: Cell Regeneration 2022 11:19
  32. Bioprinting has exhibited remarkable promises for the fabrication of functional skin substitutes. However, there are some significant challenges for the treatment of full-thickness skin defects in clinical pra...

    Authors: Changmei Niu, Liyang Wang, Dongdong Ji, Mingjun Ren, Dongxu Ke, Qiang Fu, Kaile Zhang and Xi Yang
    Citation: Cell Regeneration 2022 11:10

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