Cell Regeneration is the official journal of the Chinese Society for Cell Biology
Articles
Page 3 of 4
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Citation: Cell Regeneration 2021 10:35
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Establishment of porcine and monkey colonic organoids for drug toxicity study
Pig and monkey are widely used models for exploration of human diseases and evaluation of drug efficiency and toxicity, but high cost limits their uses. Organoids have been shown to be promising models for dru...
Citation: Cell Regeneration 2021 10:32 -
Master regulators of skeletal muscle lineage development and pluripotent stem cells differentiation
In vertebrates, the skeletal muscles of the body and their associated stem cells originate from muscle progenitor cells, during development. The specification of the muscles of the trunk, head and limbs, relie...
Citation: Cell Regeneration 2021 10:31 -
Coordination of EZH2 and SOX2 specifies human neural fate decision
Polycomb repressive complexes (PRCs) are essential in mouse gastrulation and specify neural ectoderm in human embryonic stem cells (hESCs), but the underlying molecular basis remains unclear. Here in this stud...
Citation: Cell Regeneration 2021 10:30 -
Deciphering and reconstitution of positional information in the human brain development
Organoid has become a novel in vitro model to research human development and relevant disorders in recent years. With many improvements on the culture protocols, current brain organoids could self-organize int...
Citation: Cell Regeneration 2021 10:29 -
The truth lies somewhere in the middle: the cells responsible for liver tissue maintenance finally identified
Citation: Cell Regeneration 2021 10:28 -
Emerging liver organoid platforms and technologies
Building human organs in a dish has been a long term goal of researchers in pursue of physiologically relevant models of human disease and for replacement of worn out and diseased organs. The liver has been an...
Citation: Cell Regeneration 2021 10:27 -
Scaffold strategies combined with mesenchymal stem cells in vaginal construction: a review
Tissue engineering has provided new treatment alternatives for tissue reconstruction. Advances in the tissue engineering field have resulted in mechanical support and biological substitutes to restore, maintai...
Citation: Cell Regeneration 2021 10:26 -
Role of PTEN-less in cardiac injury, hypertrophy and regeneration
Cardiovascular diseases are the leading cause of death worldwide. Cardiomyocytes are capable of coordinated contractions, which are mainly responsible for pumping blood. When cardiac stress occurs, cardiomyocy...
Citation: Cell Regeneration 2021 10:25 -
Single cells and transposable element heterogeneity in stem cells and development
Recent innovations in single cell sequencing-based technologies are shining a light on the heterogeneity of cellular populations in unprecedented detail. However, several cellular aspects are currently underut...
Citation: Cell Regeneration 2021 10:23 -
Stem/progenitor cells in fetuses and newborns: overview of immunohistochemical markers
Microanatomy of the vast majority of human organs at birth is characterized by marked differences as compared to adult organs, regarding their architecture and the cell types detectable at histology. In preter...
Citation: Cell Regeneration 2021 10:22 -
Forkhead box family transcription factors as versatile regulators for cellular reprogramming to pluripotency
Forkhead box (Fox) transcription factors play important roles in mammalian development and disease. However, their function in mouse somatic cell reprogramming remains unclear. Here, we report that FoxD subfam...
Citation: Cell Regeneration 2021 10:17 -
MRISCs protect colonic stem cells from inflammatory damage
Increasing evidence suggest functional roles of subepithelial mesenchymal niche cells in maintaining intestinal stem cells and in modulating the pathogenesis of various intestinal diseases in mammals. A recent...
Citation: Cell Regeneration 2021 10:24 -
In vivo imaging reveals mature Oligodendrocyte division in adult Zebrafish
Whether mature oligodendrocytes (mOLs) participate in remyelination has been disputed for several decades. Recently, some studies have shown that mOLs participate in remyelination by producing new sheaths. How...
Citation: Cell Regeneration 2021 10:16 -
miRNA in cardiac development and regeneration
Ischemic heart disease is one of the main causes of morbidity and mortality in the world. In adult mammalian hearts, most cardiomyocytes are terminally differentiated and have extremely limited capacity of pro...
Citation: Cell Regeneration 2021 10:14 -
Breakthrough of interspecific chimerism: blocking apoptosis
On January 28 in Nature online, Zheng et al. (Nature, 2021 (Online ahead of print)) reported that they developed an ingenious method of interspecies PSC co-culture system in vitro which unfolded interspecific ...
Citation: Cell Regeneration 2021 10:18 -
Activation of the Melanocortin-4 receptor signaling by α-MSH stimulates nerve-dependent mouse digit regeneration
Expression of Mc4r in peripheral organs indicates it has broader roles in organ homeostasis and regeneration. However, the expression and function of Mc4r in the mouse limb and digit has not been fully investi...
Citation: Cell Regeneration 2021 10:19 -
Defining cell identity beyond the premise of differential gene expression
Identifying genes that define cell identity is a requisite step for characterising cell types and cell states and predicting cell fate choices. By far, the most widely used approach for this task is based on d...
Citation: Cell Regeneration 2021 10:20 -
Organoid: a powerful tool to study lung regeneration and disease
Organoids are three-dimensional self-organizing structures formed by adult tissue stem cells or pluripotent stem cells. They recapitulate cell-cell, cell-niche interactions in tissue development, homeostasis, ...
Citation: Cell Regeneration 2021 10:21 -
Molecular regulation of myocardial proliferation and regeneration
Heart regeneration is a fascinating and complex biological process. Decades of intensive studies have revealed a sophisticated molecular network regulating cardiac regeneration in the zebrafish and neonatal mo...
Citation: Cell Regeneration 2021 10:13 -
The engine initiating tissue regeneration: does a common mechanism exist during evolution?
A successful tissue regeneration is a very complex process that requires a precise coordination of many molecular, cellular and physiological events. One of the critical steps is to convert the injury signals ...
Citation: Cell Regeneration 2021 10:12 -
The interaction of Notch and Wnt signaling pathways in vertebrate regeneration
Regeneration is an evolutionarily conserved process in animal kingdoms, however, the regenerative capacities differ from species and organ/tissues. Mammals possess very limited regenerative potential to replac...
Citation: Cell Regeneration 2021 10:11 -
Canonical and early lineage-specific stem cell types identified in planarian SirNeoblasts
The pluripotent stem cells in planarians, a model for tissue and cellular regeneration, remain further identification. We recently developed a method to enrich piwi-1+ cells in Schmidtea mediterranea, by staining...
Citation: Cell Regeneration 2021 10:15 -
RhoA/Rock activation represents a new mechanism for inactivating Wnt/β-catenin signaling in the aging-associated bone loss
The Wnt/β-catenin signaling pathway appears to be particularly important for bone homeostasis, whereas nuclear accumulation of β-catenin requires the activation of Rac1, a member of the Rho small GTPase family...
Citation: Cell Regeneration 2021 10:8 -
Proteins in DNA methylation and their role in neural stem cell proliferation and differentiation
Epigenetic modifications, namely non-coding RNAs, DNA methylation, and histone modifications such as methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation play a significant role in brain ...
Citation: Cell Regeneration 2021 10:7 -
Vertebrate cardiac regeneration: evolutionary and developmental perspectives
Cardiac regeneration is an ancestral trait in vertebrates that is lost both as more recent vertebrate lineages evolved to adapt to new environments and selective pressures, and as members of certain species de...
Citation: Cell Regeneration 2021 10:6 -
From wound response to repair – lessons from C. elegans
As a result of evolution, the ability to repair wounds allows organisms to combat environment insults. Although the general process of wound healing at the tissue level has been described for decades, the deta...
Citation: Cell Regeneration 2021 10:5 -
Cardiac cell type-specific responses to injury and contributions to heart regeneration
Heart disease is the leading cause of mortality worldwide. Due to the limited proliferation rate of mature cardiomyocytes, adult mammalian hearts are unable to regenerate damaged cardiac muscle following injur...
Citation: Cell Regeneration 2021 10:4 -
The roles and activation of endocardial Notch signaling in heart regeneration
As a highly conserved signaling pathway in metazoans, the Notch pathway plays important roles in embryonic development and tissue regeneration. Recently, cardiac injury and regeneration have become an increasi...
Citation: Cell Regeneration 2021 10:3 -
Understanding embryonic development at single-cell resolution
Citation: Cell Regeneration 2021 10:10 -
Overexpression of HOXA9 upregulates NF-κB signaling to promote human hematopoiesis and alter the hematopoietic differentiation potentials
The HOX genes are master regulators of embryogenesis that are also involved in hematopoiesis. HOXA9 belongs to a cluster of HOX genes that play extensively studied roles in hematopoiesis and leukemogenesis.
Citation: Cell Regeneration 2021 10:9 -
All routes lead to Rome: multifaceted origin of hepatocytes during liver regeneration
Liver is the largest internal organ that serves as the key site for various metabolic activities and maintenance of homeostasis. Liver diseases are great threats to human health. The capability of liver to reg...
Citation: Cell Regeneration 2021 10:2 -
The cellular niche for intestinal stem cells: a team effort
The rapidly self-renewing epithelium in the mammalian intestine is maintained by multipotent intestinal stem cells (ISCs) located at the bottom of the intestinal crypt that are interspersed with Paneth cells i...
Citation: Cell Regeneration 2021 10:1 -
Evolutionary insights into heart regeneration
Some lower vertebrates such as zebrafish and axolotl have incredible cardiac regenerative potential while mammals have very limited ones. Comparative studies among species have revealed that cardiomyocyte poly...
Citation: Cell Regeneration 2020 9:23 -
Mesenchymal stem cell as a novel approach to systemic sclerosis; current status and future perspectives
Systemic sclerosis is a rare chronic autoimmune disease with extensive microvascular injury, damage of endothelial cells, activation of immune responses, and progression of tissue fibrosis in the skin and vari...
Citation: Cell Regeneration 2020 9:20 -
Protein quality control of cell stemness
Protein quality control (PQC) systems play essential roles in the recognition, refolding and clearance of aberrant proteins, thus ensuring cellular protein homeostasis, or proteostasis. Especially, continued p...
Citation: Cell Regeneration 2020 9:22 -
Organoid based personalized medicine: from bench to bedside
Three-dimensional cultured organoids have become a powerful in vitro research tool that preserves genetic, phenotypic and behavioral trait of in vivo organs, which can be established from both pluripotent stem ce...
Citation: Cell Regeneration 2020 9:21 -
Combined application of CRISPR-Cas and stem cells for clinical and basic research
Citation: Cell Regeneration 2020 9:19 -
Immunomodulatory and Antioxidative potentials of adipose-derived Mesenchymal stem cells isolated from breast versus abdominal tissue: a comparative study
Adipose-derived stem cells (ASCs) are considered ideal candidates for both research and cellular therapy due to ease of access, large yield, feasibility, and efficacy in preclinical and clinical studies. Unlik...
Citation: Cell Regeneration 2020 9:18 -
Positive feedback between retinoic acid and 2-phospho-L-ascorbic acid trisodium salt during somatic cell reprogramming
Retinoic acid (RA) and 2-phospho-L-ascorbic acid trisodium salt (AscPNa) promote the reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells. In the current studies, the lower abilities ...
Citation: Cell Regeneration 2020 9:17 -
Erastin-induced ferroptosis is a regulator for the growth and function of human pancreatic islet-like cell clusters
Ferroptosis is a newly identified and novel form of cell death, which is characterized by an iron- and reactive oxygen species (ROS)-dependent manner. Potential utility of ferroptotic cell death has been recen...
Citation: Cell Regeneration 2020 9:16 -
Consistent apparent Young’s modulus of human embryonic stem cells and derived cell types stabilized by substrate stiffness regulation promotes lineage specificity maintenance
Apparent Young’s modulus (AYM), which reflects the fundamental mechanical property of live cells measured by atomic force microscopy and is determined by substrate stiffness regulated cytoskeletal organization...
Citation: Cell Regeneration 2020 9:15 -
Intestinal epithelial plasticity and regeneration via cell dedifferentiation
The intestinal epithelium possesses a great capacity of self-renewal under normal homeostatic conditions and of regeneration upon damages. The renewal and regenerative processes are driven by intestinal stem c...
Citation: Cell Regeneration 2020 9:14 -
Comparative characterization and osteogenic / adipogenic differentiation of mesenchymal stem cells derived from male rat hair follicles and bone marrow
Clinical applications of cell therapy and tissue regeneration under different conditions need a multiplicity of adult stem cell sources. Up to date, little is available on the comparative isolation, characteri...
Citation: Cell Regeneration 2020 9:13 -
CRISPR/Cas: a potential gene-editing tool in the nervous system
The rapidly developmental RNA-guided CRISPR/Cas system is a powerful tool for RNA and DNA editing in a variety of cells from different species and makes a great contribution to gene function research, disease ...
Citation: Cell Regeneration 2020 9:12 -
Mapping a mammalian adult adrenal gland hierarchy across species by microwell-seq
Recently, single-cell RNA-seq technologies have been rapidly updated, leading to a revolution in biology. We previously developed Microwell-seq, a cost-effective and high-throughput single cell RNA sequencing(...
Citation: Cell Regeneration 2020 9:11 -
Comparison of Scanpy-based algorithms to remove the batch effect from single-cell RNA-seq data
With the development of single-cell RNA sequencing (scRNA-seq) technology, analysts need to integrate hundreds of thousands of cells with multiple experimental batches. It is becoming increasingly difficult fo...
Citation: Cell Regeneration 2020 9:10 -
In vivo generation and regeneration of β cells in zebrafish
The pathological feature of diabetes, hyperglycemia, is a result of an inadequate number and/or function of insulin producing β cells. Replenishing functional β cells is a strategy to cure the disease. Althoug...
Citation: Cell Regeneration 2020 9:9 -
Capn3 depletion causes Chk1 and Wee1 accumulation and disrupts synchronization of cell cycle reentry during liver regeneration after partial hepatectomy
Recovery of liver mass to a healthy liver donor by compensatory regeneration after partial hepatectomy (PH) is a prerequisite for liver transplantation. Synchronized cell cycle reentry of the existing hepatocy...
Citation: Cell Regeneration 2020 9:8 -
Generation of 3D human gastrointestinal organoids: principle and applications
The stomach and intestine are important organs for food digestion, nutrient absorption, immune protection and hormone production. Gastrointestinal diseases such as cancer and ulcer are big threats to human hea...
Citation: Cell Regeneration 2020 9:6
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Official journal of
Chinese Society for Cell Biology
Annual Journal Metrics
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Citation Impact 2023
Journal Impact Factor: 4.0
5-year Journal Impact Factor: N/A
Source Normalized Impact per Paper (SNIP): 0.618
SCImago Journal Rank (SJR): 1.047Speed 2023
Submission to first editorial decision (median days): 8
Submission to acceptance (median days): 95Usage 2023
Downloads: 241,999
Altmetric mentions: 146
- ISSN: 2045-9769 (electronic)